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程侠菊
 
 
  程侠菊,副教授
电子邮箱:xjcheng[A]suda.edu.cn
通讯地址:苏州工业园区仁爱路199号, 邮编215123
 
 
          程侠菊,苏州大学医学部放射医学与防护学院副教授。2013年获得苏州大学放射医学专业学士学位,2018年获得苏州大学放射医学专业博士学位,导师高明远教授,同年入职苏州大学任师资博士后,2021年博后出站入职讲师。获得国家自然科学基金青年项目及江苏省自然科学基金青年项目,中国博士后科学基金面上项目以及特别资助项目等。在医学以及材料类学术期刊发表SCI论文20余篇,他引1200余次,2篇ESI高被引论文,部分论文发表在Adv. Mater.,ACS Nano和Cancer Res.等国际主流期刊,授权发明专利4项。  
 
  学习经历  
    2013-2018年    苏州大学,放射医学专业,博士,导师:高明远
    2008-2013年   苏州大学,放射医学专业,本科
 
  研究方向
       多功能纳米探针设计构建
       放射免疫联合治疗
      免疫响应可视化
 
  科研项目  
    1. 国家自然科学基金青年项目,81902913,PD1免疫检查点小分子抑制剂PSdis的抗肿瘤研究,20.5万,2020-01至2022-12,主持
2. 江苏省自然科学基金青年项目,BK20190821,基于PD1免疫节点小分子纳米药物的肿瘤免疫治疗研究,20万,2019-07至2022-06,主持
3. 中国博士后科学基金特别资助项目,2021T140496,PD-1赖氨酸乙酰化修饰对T细胞抗肿瘤功能的调控研究,18万,2021-07至2022-07,主持
4. 中国博士后科学基金面上项目,2019M651593,开发一种新型PD1免疫检查点小分子抑制剂及其抗癌研究,8万,2019-07至2021-08,主持
5. 放射医学与辐射防护国家重点实验室开放课题,GZK1201909,SPECT/CT 成像引导下的PD1小分子抑制剂 PSdis 肿瘤免疫治疗研究,5万,2019-06至2020-12,主持
6. 江苏省博士后科研资助计划,2021K627C,2万,2021-07至2022-07,主持
7. 苏州市科协青年科技人才托举工程计划,2万,2019-07至2019-12,主持
 
 
  代表性论文  
   
1.Vision for Ratiometric Nanoprobes: In Vivo Noninvasive Visualization and Readout of Physiological Hallmarks
Mohammad Javad Afshari#, Xiaju Cheng#, Guangxin Duan, Ruixue Duan, Shuwang Wu, Jianfeng Zeng, Zi Gu, Mingyuan Gao*
ACS Nano, 2023, 17, 7109-7134.
2. A tumor-targetable NIR probe with photoaffinity crosslinking characteristics for enhanced imaging-guided cancer phototherapy
Rui Sun#, Yuqi Zhang#, Yinjia Gao, Meng Zhao, Anna Wang, Jinfeng Zhu, Xiaju Cheng*, Haibin Shi*
Chemical Science, 2023, 14, 2369-2378.
3. Light-initiated aggregation of gold nanoparticles for synergistic chemo- photothermal tumor therapy
Huawei Xia#, Jinfeng Zhu#, Changhe Men, Anna Wang, Qiulian Mao, Yali Feng, Jiachen Li, Jingwei Xu, Xiaju Cheng*, Haibin Shi*
Nanoscale Advances
, 2023, 5, 3053-3062.
4. Antitumor potential of PD-L1/PD-1 post-translational modifications
Shimeng Zhou#, Jinfeng Zhu#, Jingwei Xu*, Bingzi Gu, Qiao Zhao, Congzhou Luo, Zhoufeng Gao, Y. Eugene Chin, Xiaju Cheng*
Immunology
, 2022, 167, 471-481.
5.Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Photothermal Therapy of Tumors
Xiaju Cheng#, Xiuxia Zhou#, Jingwei Xu#, Rui Sun, Huawei Xia, Jianan Ding, Y eugene Chin, Zhifang Chai ZF, Haibin Shi*, Mingyuan Gao*
Analytical Chemistry
, 2021, 93, 9277-9285.
6. Fabrication of multifunctional polydopamine-coated gold nanobones for PA/CT imaging and enhanced synergistic chemo-photothermal therapy
Jingwei Xu#, Xiaju Cheng#, Fuxian Chen, Weijie Li, Xiaohui Xiao, Puxiang Lai, Guopeng Xu, Li Xu, Yue Pan
Journal of Materials Science & Technology, 2021, 63, 97-105.
7. Acetylation-dependent glutamate receptor GluR signalosome formation for STAT3 activation in both transcriptional and metabolism regulation
Xiangrong Li#, Xiaju Cheng#, Jie Sun#, Yan S Xu, Nanan Chen, Yimei Hao, Chao Huang, Y eugene Chin
Cell Death Discovery, 2021, 7, 11.
8. Light-triggered Crosslinking of Gold Nanoparticles for Remarkably Improved Radiation Therapy and Computed Tomography Imaging of Tumors
Xiaju Cheng, Rui Sun, Huawei Xia, Jianan Ding, Ling Yin, Zhifang Chai, Haibin Shi*, Mingyuan Gao*
Nanomedicine
, 2019, 22(14), 2941-2955.
9. Evaluation of the structure-activity relationship of carbon nanomaterials as antioxidants
Xiaju Cheng#
, Xiaohu Ni#, Renfei Wu, Yu Chong, Xingfa Gao, Cuicui Ge*, Junjie Yin*
Nanomedicine, 2018, 13(7), 733-747.
10. Fabrication of PEGylated Fe@Bi2S3 nanocomposites for dual-mode imaging and synergistic thermoradiotherapy
Erdong Li#, Xiaju Cheng#, Yaoyao Deng, Jing Zhu, Xiaoding Xu*, Phei Er Saw, Hongwei Gu*, Cuicui Ge*, Yue Pan*
Biomatetials Science, 2018, 6(7), 1892-1898.
11. Light-triggered Assembly of Gold Nanoparticles for Photothermal Therapy and PhotoacousticImaging of Tumours In Vivo
Xiaju Cheng
, Rui Sun, Ling Yin, Zhifang Chai, Haibin Shi*, Mingyuan Gao*
Advanced Materials
, 2017, 6(29), 1604894.
12. Enhanced Radiotherapy using Bismuth Sulfide Nanoagents Combined with Photo-thermal Treatment
Xiaju Cheng#
, Yuan Yong#, Yiheng Dai, Xin Song, Gang Yang, Yue Pan*, Cuicui Ge*
Theranostics, 2017, 7(17), 4087-4098.
13. Protein Corona Influences Cellular Uptake of Gold Nanoparticles by Phagocytic and Nonphagocytic Cells in a Size-Dependent Manner.
Xiaju Cheng#
, Xin Tian#, Anqing Wu, Jianxiang Li*, Jian Tian, Yu Chong, Zhifang Chai, Yuliang Zhao, Chunying Chen, Cuicui Ge*
ACS Applied Materials & Interfaces
, 2015, 7(37), 20568-20575.
 
   
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